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British Medical Bulletin 63:5-24 (2002)
© 2002 The British Council

The molecular architecture of the inner ear

Andrew Forge and Tony Wright

UCL Centre for Auditory Research and Institute of Laryngology & Otology, University College London, London, UK

The inner ear is structurally complex. A molecular description of its architecture is now emerging from the use of contemporary methods of cell and molecular biology, and from studies of ontogenetic development. With the application of clinical and molecular genetics, it has now become possible to identify genes associated with inherited, non-syndromic deafness and balance dysfunction in humans and in mice. This work is providing new insights into how the tissues of the inner ear are built to perform their tasks, and into the pathogenesis of a range of inner ear disorders.


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