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British Medical Bulletin 64:45-58 (2002)
© 2002 Oxford University Press

Genetics – cellular basis

Advances in colorectal cancer

Andrea Buda and Massimo Pignatelli

Division of Histopathology, Department of Pathology and Microbiology, Bristol Royal Infirmary, Bristol, UK

Colorectal carcinogenesis is a multistep process during which the specialised epithelial cells of intestinal mucosa surface (e.g. colonocytes) accumulate a series of genetic and epigenetic events which lead to a perturbation of their normal cellular functions and turnover. This review will address the mechanisms and biological effects of these abnormalities on the growth control, differentiation, adhesion and survival of the colonocytes.


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