Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lythgoe, M. F
Right arrow Articles by Harris, N. G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lythgoe, M. F
Right arrow Articles by Harris, N. G
Related Collections
Right arrow Neurology
Right arrow Radiology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 65:235-257 (2003)
© 2003 The British Council

Neuroimaging of animal models of brain disease

Mark F Lythgoe*, Nicola R Sibson{dagger} and Neil G Harris{ddagger}

* RCS Unit of Biophysics, Institute of Child Health, University College London, London, UK
{dagger} MRC Biochemical & Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford, Oxford, UK
{ddagger} Academic Neurosurgery, Centre for Brain Repair & Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK

The main aim of this review is to describe some of the many animal models that have proved to be valuable from a neuroimaging perspective. This paper complements other articles in this volume, with a focus on animal models of the pathology of human brain disorders for investigations with modern non-invasive neuroimaging techniques. The use of animal model systems forms a fundamental part of neuroscience research efforts to improve the prevention, diagnosis, understanding and treatment of neurological conditions. Without such models it would be impossible to investigate such topics as the underlying mechanisms of neuronal cell damage and death, or to screen compounds for possible anticonvulsant properties. The adequacy of any one particular model depends on the suitability of information gained during experimental conditions. It is important, therefore, to understand the various types of animal model available and choose an appropriate model for the research question.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JNMHome page
C. Casteels, P. Vermaelen, J. Nuyts, A. Van Der Linden, V. Baekelandt, L. Mortelmans, G. Bormans, and K. Van Laere
Construction and Evaluation of Multitracer Small-Animal PET Probabilistic Atlases for Voxel-Based Functional Mapping of the Rat Brain
J. Nucl. Med., November 1, 2006; 47(11): 1858 - 1866.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.