Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (34)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wise, R. J S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wise, R. J S
Related Collections
Right arrow Neurology
Right arrow Radiology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 65:95-119 (2003)
© 2003 The British Council

Language systems in normal and aphasic human subjects: functional imaging studies and inferences from animal studies

Richard J S Wise

MRC Clinical Sciences Centre and Imperial College, Hammersmith Hospital, London, UK

The old neurological model of language, based on the writings of Broca, Wernicke and Lichtheim in the 19th century, is now undergoing major modifications. Observations on the anatomy and physiology of auditory processing in non-human primates are giving strong indicators as to how speech perception is organised in the human brain. In the light of this knowledge, functional activation studies with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) are achieving a new level of precision in the investigation of language organisation in the human brain, in a manner not possible with observations on patients with aphasic stroke. Although the use of functional imaging to inform methods of improving aphasia rehabilitation remains underdeveloped, there are strong indicators that this methodology will provide the means to research a very imperfectly developed area of therapy.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
M. A. Lambon Ralph, K. Sage, R. W. Jones, and E. J. Mayberry
Coherent concepts are computed in the anterior temporal lobes
PNAS, February 9, 2010; 107(6): 2717 - 2722.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. F. Schwartz, D. Y. Kimberg, G. M. Walker, O. Faseyitan, A. Brecher, G. S. Dell, and H. B. Coslett
Anterior temporal involvement in semantic word retrieval: voxel-based lesion-symptom mapping evidence from aphasia
Brain, December 1, 2009; 132(12): 3411 - 3427.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. A. Lambon Ralph, G. Pobric, and E. Jefferies
Conceptual Knowledge Is Underpinned by the Temporal Pole Bilaterally: Convergent Evidence from rTMS
Cereb Cortex, April 1, 2009; 19(4): 832 - 838.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Saur, B. W. Kreher, S. Schnell, D. Kummerer, P. Kellmeyer, M.-S. Vry, R. Umarova, M. Musso, V. Glauche, S. Abel, et al.
Ventral and dorsal pathways for language
PNAS, November 18, 2008; 105(46): 18035 - 18040.
[Abstract] [Full Text] [PDF]

Home page
 Neurorehabil Neural RepairHome page
Abstracts for the 5th World Congress of NeuroRehabilitation
Neurorehabil Neural Repair, September 1, 2008; 22(5): 514 - 640.
[PDF]

Home page
 Am. J. Neuroradiol.Home page
J.I. Breier, K.M. Hasan, W. Zhang, D. Men, and A.C. Papanicolaou
Language Dysfunction After Stroke and Damage to White Matter Tracts Evaluated Using Diffusion Tensor Imaging
AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 483 - 487.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Pobric, E. Jefferies, and M. A. L. Ralph
Anterior temporal lobes mediate semantic representation: Mimicking semantic dementia by using rTMS in normal participants
PNAS, December 11, 2007; 104(50): 20137 - 20141.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. E. Hillis
Aphasia: Progress in the last quarter of a century
Neurology, July 10, 2007; 69(2): 200 - 213.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. R. Crandall, M. Adam, A. K. Kinnischtzke, and T. A. Nick
HVC Neural Sleep Activity Increases With Development and Parallels Nightly Changes in Song Behavior
J Neurophysiol, July 1, 2007; 98(1): 232 - 240.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. DeLeon, R. F. Gottesman, J. T. Kleinman, M. Newhart, C. Davis, J. Heidler-Gary, A. Lee, and A. E. Hillis
Neural regions essential for distinct cognitive processes underlying picture naming
Brain, May 1, 2007; 130(5): 1408 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. A. Lambon Ralph, C. Lowe, and T. T. Rogers
Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network model
Brain, April 1, 2007; 130(4): 1127 - 1137.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. Saur, R. Lange, A. Baumgaertner, V. Schraknepper, K. Willmes, M. Rijntjes, and C. Weiller
Dynamics of language reorganization after stroke
Brain, June 1, 2006; 129(6): 1371 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J.-F. Demonet, G. Thierry, and D. Cardebat
Renewal of the Neurophysiology of Language: Functional Neuroimaging
Physiol Rev, January 1, 2005; 85(1): 49 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Behav Cogn Neurosci RevHome page
R. H. Fitch and P. Tallal
Neural Mechanisms of Language-Based Learning Impairments: Insights from Human Populations and Animal Models
Behav Cogn Neurosci Rev, September 1, 2003; 2(3): 155 - 178.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.