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British Medical Bulletin 2005 71(1):115-135; doi:10.1093/bmb/ldh034
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Published online 22 February 2005

British Medical Bulletin, Vol. 71 © The British Council 2005; all rights reserved

Xenon: elemental anaesthesia in clinical practice

Robert D. Sanders*,{ddagger}, Daqing Ma* and Mervyn Maze*,{dagger},{ddagger}

* Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, UK, {dagger} Biophysics Section, Department of Biological Sciences, Imperial College London, UK and {ddagger} Magill Department of Anaesthesia, Intensive Care and Pain Management, Chelsea and Westminster Hospital, Chelsea and Westminster Healthcare NHS Trust, London, UK

Correspondence to: Professor Mervyn Maze, Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, UK. E-mail: m.maze{at}ic.ac.uk

The ‘noble’ gases have been known to have anaesthetic properties for 50 years yet only recently has their application become a clinical reality. In this review we describe the preclinical and clinical studies that have led to a resurgence of interest in the use of the element xenon as an anaesthetic. Furthermore, we highlight specific areas where xenon demonstrates advantages over other anaesthetics, including safety, beneficial pharmacokinetics, cardiovascular stability, analgesia and neuroprotection.


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