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British Medical Bulletin 2005 72(1):135-148; doi:10.1093/bmb/ldh045
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Published online 21 April 2005

© The Author 2005. Published by Oxford University Press on behalf of The British Council. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Advances in epilepsy

Andrew R. C. Kelso and Hannah R. Cock**

Epilepsy Group, Centre for Clinical Neurosciences, St George’s University of London, Cranmer Terrace, London SW17 0RE, UK

* Correspondence to: Dr Hannah R. Cock, Epilepsy Group, Clinical Neurosciences, St George’s Hospital Medical School, Cranmer Terrace, London SW17 0RE. E-mail: hcock{at}sghms.ac.uk

Advances in understanding of both the causes and consequences of epilepsy have been paralleled by a number of recent reports and clinical guidelines highlighting the complexities involved in both diagnosing and treating epilepsy. We review recent developments, including comments on the evolution of clinical guidelines, anti-epileptic drugs, epilepsy surgery and new treatment approaches in development. Epilepsy genetics and emerging evidence on mechanisms of drug resistance in epilepsy will also be discussed. Issues with respect to pregnancy and epilepsy are considered, together with more recently identified dilemmas including bone health in epilepsy and whether seizures themselves cause brain damage. Imaging in epilepsy has recently been reviewed elsewhere, and will not be discussed.


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