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British Medical Bulletin 2005 72(1):65-81; doi:10.1093/bmb/ldh041
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Published online 31 March 2005

© The Author 2005. Published by Oxford University Press on behalf of The British Council. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Vaccines against bacterial meningitis

S. Segal* and A. J. Pollard{dagger}

Department of Paediatrics, University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK.

{dagger} Declaration of interest. AJP conducts trials of meningitis vaccines on behalf of the University of Oxford sponsored by manufacturers of childhood vaccines. AJP has received travel funds for attendance at scientific meetings from vaccine manufactures but has not received consultancy fees. AJP is an inventor on a patent application in the area of Men B vaccines.

* Correspondence to: S. Segal, Department of Paediatrics, University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK. E-mail: Shelley.segal{at}paediatrics.oxford.ac.uk

Meningitis remains an important cause of morbidity and mortality among children >5 years of age and is especially prevalent in developing countries. Effective routine immunization against Hib, pneumococcus and serogroupC meningococcus has had a significant impact on both invasive disease and carriage caused by these encapsulated bacteria. The major challenge in prevention of meningitis remains the delivery of vaccines worldwide, especially to resource-poor regions with the greatest disease burden.


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