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British Medical Bulletin Advance Access originally published online on April 8, 2008
British Medical Bulletin 2008 86(1):109-127; doi:10.1093/bmb/ldn013
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

A review of Parkinson's disease

C. A. Davie

The Royal Free Hospital NHS Trust, Hampstead, London NW3 2QG, UK

Correspondence to: C. A. Davie, The Royal Free Hospital NHS Trust, Hampstead, London NW3 2QG, UK. E-mail: c.davie{at}medsch.ucl.ac.uk

Introduction: Parkinson's disease (PD) is one of the most common neurodegenerative disorders.

Sources of data: Literature search using Medline with keywords Parkinson's disease supplemented with previously published papers known to the author.

Areas of agreement: There have been significant recent advances in the understanding of the pathogenesis of the disease. There has also been a greater realization that the disorder may be associated with significant non-motor disturbances in addition to the more commonly recognized motor complications.

Areas of controversy: Although there is growing circumstantial evidence, it remains to be proven whether any of the current treatments for PD have a neuroprotective effect.

Areas timely for developing research: Although there is no cure, there are several management options for the early treatment of PD. As the disease progresses, further treatment options are available; however, the management of late-stage motor complications and non-motor symptoms remains particularly challenging and will benefit from further clinical research.

Keywords: Parkinson's disease • motor complications • non-motor complications

Accepted for publication February 13, 2008.


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