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British Medical Bulletin Advance Access originally published online on August 22, 2008
British Medical Bulletin 2008 87(1):63-75; doi:10.1093/bmb/ldn030
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

The social behaviours of bacterial pathogens

Roman Popat, Shanika A. Crusz and Stephen P. Diggle*

Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University Park, University of Nottingham, Nottingham NG7 2RD, UK

* Correspondence to: Stephen P. Diggle, Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University Park, University of Nottingham, Nottingham NG7 2RD, UK. E-mail: steve.diggle{at}nottingham.ac.uk

Introduction: The term quorum sensing (QS) is used to describe communication between bacterial cells, whereby a coordinated population response is controlled by diffusible signal molecules produced by individuals.

Sources of data: Studies on QS-mediated signalling processes in bacteria have revealed the existence of intricate regulatory networks to enable bacterial populations to fine tune their responses to environmental changes and increase their chances of survival, using complex signalling pathways.

Areas of agreement: A population of bacteria invading a host may benefit from the coordinated release of virulence determinants and in vitro studies have shown that QS regulates virulence factor production in many species of bacteria.

Areas of controversy: However, the role of QS in vivo is less well understood, but has been demonstrated to be important in several pathogenic organisms.

Growing points and areas timely for developing research: There is a growing interest in blocking bacterial cell–cell communication as a means to control infections. This review discusses QS from a pathogenic perspective and discusses the potential of QS as an anti-pathogenic target.

Keywords: quorum sensing • Pseudomonas aeruginosa

Accepted for publication July 28, 2008.


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