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British Medical Bulletin 41:281-286 (1985)
© 1985 The British Council

research-article

THE COMPLEMENT SYSTEM IN SEPSIS AND TRAUMA

A R McPhaden and K Whaley

University of Glasgow Department of Pathology, Western Infirmary Glasgow

Abstract

Activation of the complement system plays a crucial role in determining the outcome of sepsis and trauma. Effective antimicrobial activity is the main beneficial result of controlled complement activation in sepsis. However, massive complement activation, as occurs in endotoxaemia, contributes to the development of the adult respiratory distress syndrome and possibly endotoxic shock. The mechanisms of their pathogenesis are discussed. The important contributions of complement activation in burn injury, pancreatitis and adverse reactions to radiographic contrast media are described.


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