| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
British Medical Bulletin 47:87-98 (1991)
© 1991 The British Council
research-article |
Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers
ICRF Oncology Group, Royal Postgraduate Medical School, Hammersmith Hospital London
Abstract
This chapter reviews briefly the prevalence of overexpression of the epidermal growth factor receptor in human cancers. In addition, it examines the mechanisms responsible for increased expression and its clinical significance.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. J. Lammerts van Bueren, W. K. Bleeker, A. Brannstrom, A. von Euler, M. Jansson, M. Peipp, T. Schneider-Merck, T. Valerius, J. G. J. van de Winkel, and P. W. H. I. Parren The antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility PNAS, April 22, 2008; 105(16): 6109 - 6114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Huang, J. Hu, X. Bian, K. Chen, W. Gong, N. M. Dunlop, O.M. Z. Howard, and J. M. Wang Transactivation of the Epidermal Growth Factor Receptor by Formylpeptide Receptor Exacerbates the Malignant Behavior of Human Glioblastoma Cells Cancer Res., June 15, 2007; 67(12): 5906 - 5913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fang, D. Hawke, Y. Zheng, Y. Xia, J. Meisenhelder, H. Nika, G. B. Mills, R. Kobayashi, T. Hunter, and Z. Lu Phosphorylation of beta-Catenin by AKT Promotes beta-Catenin Transcriptional Activity J. Biol. Chem., April 13, 2007; 282(15): 11221 - 11229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Ramnarain, S. Park, D. Y. Lee, K. J. Hatanpaa, S. O. Scoggin, H. Otu, T. A. Libermann, J. M. Raisanen, R. Ashfaq, E. T. Wong, et al. Differential Gene Expression Analysis Reveals Generation of an Autocrine Loop by a Mutant Epidermal Growth Factor Receptor in Glioma Cells Cancer Res., January 15, 2006; 66(2): 867 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. del Carmen, I. Rizvi, Y. Chang, A. C. E. Moor, E. Oliva, M. Sherwood, B. Pogue, and T. Hasan Synergism of Epidermal Growth Factor Receptor-Targeted Immunotherapy With Photodynamic Treatment of Ovarian Cancer In Vivo J Natl Cancer Inst, October 19, 2005; 97(20): 1516 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Leibl and F Moinfar Metaplastic breast carcinomas are negative for Her-2 but frequently express EGFR (Her-1): potential relevance to adjuvant treatment with EGFR tyrosine kinase inhibitors? J. Clin. Pathol., July 1, 2005; 58(7): 700 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A E Wakeling Inhibitors of growth factor signalling Endocr. Relat. Cancer, July 1, 2005; 12(Supplement_1): S183 - S187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Camp, J. Summy, T. W. Bauer, W. Liu, G. E. Gallick, and L. M. Ellis Molecular Mechanisms of Resistance to Therapies Targeting the Epidermal Growth Factor Receptor Clin. Cancer Res., January 1, 2005; 11(1): 397 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. F. Solca, A. Baum, E. Langkopf, G. Dahmann, K.-H. Heider, F. Himmelsbach, and J. C. A. van Meel Inhibition of Epidermal Growth Factor Receptor Activity by Two Pyrimidopyrimidine Derivatives J. Pharmacol. Exp. Ther., November 1, 2004; 311(2): 502 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Schechter, R. E. Wendt III, D. J. Yang, A. Azhdarinia, W. D. Erwin, A. M. Stachowiak, L. D. Broemeling, E. E. Kim, J. D. Cox, D. A. Podoloff, et al. Radiation Dosimetry of 99mTc-Labeled C225 in Patients with Squamous Cell Carcinoma of the Head and Neck J. Nucl. Med., October 1, 2004; 45(10): 1683 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. K. Bleeker, J. J. Lammerts van Bueren, H. H. van Ojik, A. F. Gerritsen, M. Pluyter, M. Houtkamp, E. Halk, J. Goldstein, J. Schuurman, M. A. van Dijk, et al. Dual Mode of Action of a Human Anti-Epidermal Growth Factor Receptor Monoclonal Antibody for Cancer Therapy J. Immunol., October 1, 2004; 173(7): 4699 - 4707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Perez-Soler, A. Chachoua, L. A. Hammond, E. K. Rowinsky, M. Huberman, D. Karp, J. Rigas, G. M. Clark, P. Santabarbara, and P. Bonomi Determinants of Tumor Response and Survival With Erlotinib in Patients With Non--Small-Cell Lung Cancer J. Clin. Oncol., August 15, 2004; 22(16): 3238 - 3247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Park, R. S. Kerbel, G. J. Kelloff, J. C. Barrett, B. A. Chabner, D. R. Parkinson, J. Peck, R. W. Ruddon, C. C. Sigman, and D. J. Slamon Rationale for Biomarkers and Surrogate End Points in Mechanism-Driven Oncology Drug Development Clin. Cancer Res., June 1, 2004; 10(11): 3885 - 3896. [Full Text] [PDF]
|
|
|
|
|
|
P. Chen, R. Cameron, J. Wang, K. A. Vallis, and R. M. Reilly Antitumor Effects and Normal Tissue Toxicity of 111In-Labeled Epidermal Growth Factor Administered to Athymic Mice Bearing Epidermal Growth Factor Receptor-Positive Human Breast Cancer Xenografts J. Nucl. Med., September 1, 2003; 44(9): 1469 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Anto, M. Venkatraman, and D. Karunagaran Inhibition of NF-{kappa}B Sensitizes A431 Cells to Epidermal Growth Factor-induced Apoptosis, whereas Its Activation by Ectopic Expression of RelA Confers Resistance J. Biol. Chem., July 3, 2003; 278(28): 25490 - 25498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Habib, S. J. Chun, B. G. Neel, and T. Vartanian Increased Expression of Epidermal Growth Factor Receptor Induces Sequestration of Extracellular Signal-Related Kinases and Selective Attenuation of Specific Epidermal Growth Factor-Mediated Signal Transduction Pathways Mol. Cancer Res., January 1, 2003; 1(3): 219 - 233. [Abstract] [Full Text]
|
|
|
|
 |
|
 A J Colquhoun and J K Mellon Epidermal growth factor receptor and bladder cancer Postgrad. Med. J., October 1, 2002; 78(924): 584 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Myers, F. C. Holsinger, B. N. Bekele, E. Li, S. A. Jasser, J. J. Killion, and I. J. Fidler Targeted Molecular Therapy for Oral Cancer With Epidermal Growth Factor Receptor Blockade: A Preliminary Report Arch Otolaryngol Head Neck Surg, August 1, 2002; 128(8): 875 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Peghini, M. Iwamoto, M. Raffeld, Y.-J. Chen, S. U. Goebel, J. Serrano, and R. T. Jensen Overexpression of Epidermal Growth Factor and Hepatocyte Growth Factor Receptors in a Proportion of Gastrinomas Correlates with Aggressive Growth and Lower Curability Clin. Cancer Res., July 1, 2002; 8(7): 2273 - 2285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. G. Keshamouni, R. R. Mattingly, and K. B. Reddy Mechanism of 17-beta -Estradiol-induced Erk1/2 Activation in Breast Cancer Cells. A ROLE FOR HER2 AND PKC-delta J. Biol. Chem., June 14, 2002; 277(25): 22558 - 22565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. A. Elsayed and E. A. Sausville Selected Novel Anticancer Treatments Targeting Cell Signaling Proteins Oncologist, December 1, 2001; 6(6): 517 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Baron, J. M. Lafky, V. J. Suman, D. W. Hillman, M. C. Buenafe, C. H. Boardman, K. C. Podratz, E. A. Perez, and N. J. Maihle A Preliminary Study of Serum Concentrations of Soluble Epidermal Growth Factor Receptor (sErbB1), Gonadotropins, and Steroid Hormones in Healthy Men and Women Cancer Epidemiol. Biomarkers Prev., November 1, 2001; 10(11): 1175 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Lu, G. Jiang, P. Blume-Jensen, and T. Hunter Epidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase Mol. Cell. Biol., June 15, 2001; 21(12): 4016 - 4031. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Yu, A. K. Rishi, J. R. Turner, D. Liu, E. D. Black, J. A. Moshier, and A. P. N. Majumdar Cloning of a novel EGFR-related peptide: a putative negative regulator of EGFR Am J Physiol Cell Physiol, May 1, 2001; 280(5): C1083 - C1089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hambek, C. Solbach, H.-G. Schnuerch, M. Roller, M. Stegmueller, A. Sterner-Kock, J. Kiefer, and R. Knecht Tumor Necrosis Factor {{alpha}} Sensitizes Low Epidermal Growth Factor Receptor (EGFR)-expressing Carcinomas for Anti-EGFR Therapy Cancer Res., February 1, 2001; 61(3): 1045 - 1049. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. E. Marjou, A. Delouvee, J. P. Thiery, and F. Radvanyi Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression Carcinogenesis, December 1, 2000; 21(12): 2211 - 2218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Bonner, K. P. Raisch, H. Q. Trummell, F. Robert, R. F. Meredith, S. A. Spencer, D. J. Buchsbaum, M. N. Saleh, M. A. Stackhouse, A. F. LoBuglio, et al. Enhanced Apoptosis With Combination C225/Radiation Treatment Serves as the Impetus for Clinical Investigation in Head and Neck Cancers J. Clin. Oncol., November 1, 2000; 18(90001): 47s - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Arcaro, M. J. Zvelebil, C. Wallasch, A. Ullrich, M. D. Waterfield, and J. Domin Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors Mol. Cell. Biol., June 1, 2000; 20(11): 3817 - 3830. [Abstract] [Full Text]
|
|
|
|
|
|
C. K. Tang, X.-Q. Gong, D. K. Moscatello, A. J. Wong, and M. E. Lippman Epidermal Growth Factor Receptor vIII Enhances Tumorigenicity in Human Breast Cancer Cancer Res., June 1, 2000; 60(11): 3081 - 3087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Donato, M. Perez, H. Kang, Z. H. Siddik, Y.-H. Ling, and R. Perez-Soler EGF Receptor and p21WAF1 Expression are Reciprocally Altered as ME-180 Cervical Carcinoma Cells Progress from High to Low Cisplatin Sensitivity Clin. Cancer Res., January 1, 2000; 6(1): 193 - 202. [Abstract] [Full Text]
|
|
|
|
|
|
V. A. Pollack, D. M. Savage, D. A. Baker, K. E. Tsaparikos, D. E. Sloan, J. D. Moyer, E. G. Barbacci, L. R. Pustilnik, T. A. Smolarek, J. A. Davis, et al. Inhibition of Epidermal Growth Factor Receptor-Associated Tyrosine Phosphorylation in Human Carcinomas with CP-358,774: Dynamics of Receptor Inhibition In Situ and Antitumor Effects in Athymic Mice J. Pharmacol. Exp. Ther., November 1, 1999; 291(2): 739 - 748. [Abstract] [Full Text]
|
|
|
|
|
|
C. K. Tang, X.-Z. W. Concepcion, M. Milan, X. Gong, E. Montgomery, and M. E. Lippman Ribozyme-mediated Down-Regulation of ErbB-4 in Estrogen Receptor-positive Breast Cancer Cells Inhibits Proliferation Both in Vitro and in Vivo Cancer Res., October 1, 1999; 59(20): 5315 - 5322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shintani, K. Matsuo, C. C. Crohin, J. McBride, T. Tsuji, R. B. Donoff, M. Posner, R. Todd, and D. T.W. Wong Intragenic Mutation Analysis of the Human Epidermal Growth Factor Receptor (EGFR) Gene in Malignant Human Oral Keratinocytes Cancer Res., August 1, 1999; 59(16): 4142 - 4147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tan, R. Grijalva, and D. Yu Heregulin {beta}1-activated Phosphatidylinositol 3-Kinase Enhances Aggregation of MCF-7 Breast Cancer Cells Independent of Extracellular Signal-regulated Kinase Cancer Res., April 1, 1999; 59(7): 1620 - 1625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-D. Yang, X.-C. Jia, J. R. F. Corvalan, P. Wang, C. G. Davis, and A. Jakobovits Eradication of Established Tumors by a Fully Human Monoclonal Antibody to the Epidermal Growth Factor Receptor without Concomitant hemotherapy Cancer Res., March 1, 1999; 59(6): 1236 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-M. Wang, A. Kuo, M. Alimandi, M. C. Veri, C.-C. Lee, V. Kapoor, N. Ellmore, X.-H. Chen, and J. H. Pierce ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4 PNAS, June 9, 1998; 95(12): 6809 - 6814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Bor, B. S. Sorensen, P. Rammer, and E. Nexo Calibrated user-friendly reverse transcriptase-PCR assay: quantitation of epidermal growth factor receptor mRNA Clin. Chem., June 1, 1998; 44(6): 1154 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Silvy, P.-M. Martin, N. Chajry, and Y. Berthois Differential Dose-Dependent Effects of Epidermal Growth Factor on Gene Expression in A431 Cells: Evidence for a Signal Transduction Pathway That Can Bypass Raf-1 Activation Endocrinology, May 1, 1998; 139(5): 2382 - 2391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E J Kelly, S J Newell, K G Brownlee, S M Farmery, C Cullinane, W A Reid, P Jackson, S F Gray, J N Primrose, and M Lagopoulos Role of epidermal growth factor and transforming growth factor alpha in the developing stomach Arch. Dis. Child. Fetal Neonatal Ed., May 1, 1997; 76(3): 158F - 162. [Abstract] [Full Text]
|
|
|
|
|
|
S. A. Prigent, M. Nagane, H. Lin, I. Huvar, G. R. Boss, J. R. Feramisco, W. K. Cavenee, and H.-J. S. Huang Enhanced Tumorigenic Behavior of Glioblastoma Cells Expressing a Truncated Epidermal Growth Factor Receptor Is Mediated through the Ras-Shc-Grb2 Pathway J. Biol. Chem., October 11, 1996; 271(41): 25639 - 25645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Beerli and N. E. Hynes Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities J. Biol. Chem., March 15, 1996; 271(11): 6071 - 6076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Habib, S. Chatterjee, S.-K. Park, R. R. Ratan, S. Lefebvre, and T. Vartanian The Epidermal Growth Factor Receptor Engages Receptor Interacting Protein and Nuclear Factor-kappa B (NF-kappa B)-inducing Kinase to Activate NF-kappa B. IDENTIFICATION OF A NOVEL RECEPTOR-TYROSINE KINASE SIGNALOSOME J. Biol. Chem., March 16, 2001; 276(12): 8865 - 8874. [Abstract] [Full Text] [PDF]
|
|