Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (31)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kopelman, P. G
Right arrow Articles by Albon, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kopelman, P. G
Right arrow Articles by Albon, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 53:322-340 (1997)
© 1997 The British Council

research-article

Obseity, non-insulin-dependent diabetes mellitus and the metabolic syndrome

Peter G Kopelman and Lorraine Albon

St Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College London, UK

Correspondence to: Dr Peter Kopelman, Medical Unit, Royal London Hospital, London E1 1BB, UK

Abstract

Obesity i s characterised by alterations in metabolic function which result from a combination of increasing total body fatness and the regional distribution of adipose tissue. Abdominal visceral obesity is particularly associated with hyperinsulinaernia, increased portal vein free fatty acid concentration, hepatic gluconeogenesis, altered adrenocortical activity and androgen secretion and reduced plasma sex hormone binding globulin levels. These alterations, which are accompanied by changes in visceral adipocyte sensitivity to plasma catecholamine stimulation, enhance further visceral fat deposition and the perpetuation of the metabolic derangements. The characteristic dyslipidaemia associated with upper body obesity and the frequent development of NIDDM are predictable consequences. In contrast to the considerable knowledge about the biochemical background to these alterations, relatively little is understood about the mechanisms through which an individual's ethnic background influences the changes. This chapter reviews these important issues.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
C. Petibois, A. Cassaigne, H. Gin, and G. Deleris
Lipid Profile Disorders Induced by Long-Term Cessation of Physical Activity in Previously Highly Endurance-Trained Subjects
J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3377 - 3384.
[Abstract] [Full Text] [PDF]

Home page
 PsychosomaticsHome page
J. M. Lafayette, W. F. Pirl, and D. C. Henderson
Low-Dose Clozapine and Diabetic Ketoacidosis
Psychosomatics, June 1, 2003; 44(3): 249 - 252.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. D. Kriketos, S. M. Furler, S. K. Gan, A. M. Poynten, D. J. Chisholm, and L. V. Campbell
Multiple Indexes of Lipid Availability Are Independently Related to Whole Body Insulin Action in Healthy Humans
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 793 - 798.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. J. Loos, G. Beunen, R. Fagard, C. Derom, and R. Vlietinck
Birth weight and body composition in young women: a prospective twin study
Am. J. Clinical Nutrition, April 1, 2002; 75(4): 676 - 682.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M.-T. van der Merwe, G. P. Schlaphoff, N. J. Crowther, I. H. Boyd, I. P. Gray, B. I. Joffe, and P. N. Lonnroth
Lactate and Glycerol Release from Adipose Tissue in Lean, Obese, and Diabetic Women from South Africa
J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3296 - 3303.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. A. Heinlein, H.-J. Ting, S. Yeh, and C. Chang
Identification of ARA70 as a Ligand-enhanced Coactivator for the Peroxisome Proliferator-activated Receptor gamma
J. Biol. Chem., June 4, 1999; 274(23): 16147 - 16152.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.