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British Medical Bulletin 53:478-490 (1997)
© 1997 The British Council
research-article |
The caspase family of cysteine proteases
Department of Biochemistry, Merck Research Laboratories Rahway, New Jersey, USA
Nancy A Thornberry, Merck Research Laborotories, Department of Biochemistry, R80W-250, PO Box 2000, Rahway, NJ 07065, USA
Abstract
The discovery that CED-3, the product of a gene necessary for programmed cell death in the nematode Caenorhabditis elegans, is related to the mammalian cysteine protease interleukin-1ßconverting enzyme (ICE/caspase-1) has led to intense interest in the role of proteases in apoptosis. It is now clear that at least some members of the caspase (ICE/CED-3) family, which at present includes ten homologues of human origin, are essential components of an evolutionarily conserved pathway of apoptosis. These enzymes appear to be involved in both the initial signaling events and the downstream proteolytic cleavages that result in the apoptotic phenotype. Selective macromolecular and peptide-based inhibitors attenuate apoptosis in whole cells, suggesting that one or more of these enzymes will be suitable targets for therapeutic intervention in diseases resulting from inappropriate cell death.
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