Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (37)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Young, L. S
Right arrow Articles by Eliopoulos, A. G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Young, L. S
Right arrow Articles by Eliopoulos, A. G
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Medical Bulletin 53:509-521 (1997)
© 1997 The British Council

research-article

Viruses and apoptosis

Lawrence S Young, Christopher W Dawson and Aristides G Eliopoulos

CRS Institute for Cancer Studies, University of Birmingham Medical School Birmingham, UK

Prof Lawrence S Young, CRC Institute for Cancer Studies, University of Birmingham Medical School, Birmingham B15 2TJ, UK

Abstract

Virus infection and replication are often associated with apoptosis and this effect is likely to be responsible for much of the pathology associated with infectious disease. Many viruses encode proteins which can inhibit apoptosis thereby either prolonging the survival of infected cells such that the production of progeny virus is maximised or facilitating the establishment of virus persistence. These viral proteins target the cellular pathways responsible for regulating apoptosis and have been instrumental in furthering our understanding of the apoptotic process. Many of the viruses associated with oncogenic transformation have adopted strategies for blocking apoptosis highlighting the centrality of this effect in carcinogensis. Understading the mechanisms by which viruses regulate apoptosis may lead to the development of novel therapies for both infectious disease and cancer.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Gen. Virol.Home page
L.-Y. Li, M.-Y. Liu, H.-M. Shih, C.-H. Tsai, and J.-Y. Chen
Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival.
J. Gen. Virol., October 1, 2006; 87(Pt 10): 2869 - 2878.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
E. Turpin, K. Luke, J. Jones, T. Tumpey, K. Konan, and S. Schultz-Cherry
Influenza Virus Infection Increases p53 Activity: Role of p53 in Cell Death and Viral Replication
J. Virol., July 15, 2005; 79(14): 8802 - 8811.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
S. Cooray, J. M. Best, and L. Jin
Time-course induction of apoptosis by wild-type and attenuated strains of rubella virus
J. Gen. Virol., May 1, 2003; 84(5): 1275 - 1279.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. Hagglund, J. Munger, A. P. W. Poon, and B. Roizman
US3 Protein Kinase of Herpes Simplex Virus 1 Blocks Caspase 3 Activation Induced by the Products of US1.5 and UL13 Genes and Modulates Expression of Transduced US1.5 Open Reading Frame in a Cell Type-Specific Manner
J. Virol., January 15, 2002; 76(2): 743 - 754.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Schultz-Cherry, N. Dybdahl-Sissoko, G. Neumann, Y. Kawaoka, and V. S. Hinshaw
Influenza Virus NS1 Protein Induces Apoptosis in Cultured Cells
J. Virol., September 1, 2001; 75(17): 7875 - 7881.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
K. A. Gottlieb and L. P. Villarreal
Natural Biology of Polyomavirus Middle T Antigen
Microbiol. Mol. Biol. Rev., June 1, 2001; 65(2): 288 - 318.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. Shirin, E. M. Sordillo, T. K. Kolevska, H. Hibshoosh, Y. Kawabata, S. H. Oh, J. F. Kuebler, T. Delohery, C. M. Weghorst, I. B. Weinstein, et al.
Chronic Helicobacter pylori Infection Induces an Apoptosis-Resistant Phenotype Associated with Decreased Expression of p27kip1
Infect. Immun., September 1, 2000; 68(9): 5321 - 5328.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
C. A. Meseda, J. R. Arrand, and M. Mackett
Herpesvirus papio encodes a functional homologue of the Epstein-Barr virus apoptosis suppressor, BHRF1
J. Gen. Virol., July 1, 2000; 81(7): 1801 - 1805.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. G. Eliopoulos, N. J. Gallagher, S. M. S. Blake, C. W. Dawson, and L. S. Young
Activation of the p38 Mitogen-activated Protein Kinase Pathway by Epstein-Barr Virus-encoded Latent Membrane Protein 1 Coregulates Interleukin-6 and Interleukin-8 Production
J. Biol. Chem., June 4, 1999; 274(23): 16085 - 16096.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. G. Eliopoulos, S. M. S. Blake, J. E. Floettmann, M. Rowe, and L. S. Young
Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Activates the JNK Pathway through Its Extreme C Terminus via a Mechanism Involving TRADD and TRAF2
J. Virol., February 1, 1999; 73(2): 1023 - 1035.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
C. W. Dawson, J. Dawson, R. Jones, K. Ward, and L. S. Young
Functional Differences between BHRF1, the Epstein-Barr Virus-Encoded Bcl-2 Homologue, and Bcl-2 in Human Epithelial Cells
J. Virol., November 1, 1998; 72(11): 9016 - 9024.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.